BDBM13224 2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1,3-thiazole-2,5-diamido::BMS-354825 2-Amino-4-methyl-thiazole Analog 7d::CHEMBL130719

SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C

InChI Key InChIKey=LEOANBUEWRQPOF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13224   

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

LigandPNGBDBM13224(CHEMBL130719 | 2-N-benzene-4-methyl-5-N-(2,4,6-tri...)
Affinity DataIC50: 800nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Bristol-Myers Squibb

LigandPNGBDBM13224(CHEMBL130719 | 2-N-benzene-4-methyl-5-N-(2,4,6-tri...)
Affinity DataIC50: 320nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

LigandPNGBDBM13224(CHEMBL130719 | 2-N-benzene-4-methyl-5-N-(2,4,6-tri...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CD3/CD28 T-cell proliferation assay in PBL (peripheral blood lymphocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Bristol-Myers Squibb

LigandPNGBDBM13224(CHEMBL130719 | 2-N-benzene-4-methyl-5-N-(2,4,6-tri...)
Affinity DataIC50: 320nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed