BDBM13126 (2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-3-methylbutanamide::CGS 27023A Analog 58::CHEMBL85030

SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](C(C)C)C(=O)NO

InChI Key InChIKey=ZGSTVUAZFACDLH-UHFFFAOYSA-N

Data  19 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 13126   

TargetCollagenase 3(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Mouse)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 4.90nMAssay Description:Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of MMP-12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 8nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 27nMAssay Description:Inhibition of MMP-9 (unknown origin) using 7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MMP-2 (unknown origin) using 7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataIC50: 33nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNeutrophil collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of MMP-8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCollagenase 3(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of MMP-13 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human MMP-9 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  8nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  11nMAssay Description:Inhibition of human active MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant MMP-2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNeutrophil collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP-8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP8 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  27nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  27nMAssay Description:Inhibition of MMP9 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  27nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  33nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant MMP-1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  34nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  43nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM13126(CHEMBL85030 | (2R)-2-[benzyl(4-methoxybenzene)sulf...)
Affinity DataKi:  43nMAssay Description:Inhibition of human recombinant MMP-3 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed