BDBM130435 US8822505, 37::US8822505, 38

SMILES C[C@H](Oc1ccc(c(Cl)c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CCN1)c1ncc(Cl)cc1F)C(=O)NC1(CC1)C#N)C(F)(F)F

InChI Key InChIKey=LQXJTYUJAKLJDS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 130435   

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130435(US8822505, 38 | US8822505, 37)
Affinity DataIC50: 58.5nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130435(US8822505, 38 | US8822505, 37)
Affinity DataIC50: 317nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130435(US8822505, 38 | US8822505, 37)
Affinity DataIC50: 3.83nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130435(US8822505, 38 | US8822505, 37)
Affinity DataIC50: 4.16nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent