BDBM130431 US8822505, 33

SMILES C[C@H](Oc1ccc(c(Cl)c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CN(C1)C(=O)OC(C)(C)C)c1ncc(Br)cc1F)C(=O)NC1(CC1)C#N)C(F)(F)F

InChI Key InChIKey=ISMUQAIURWHJMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 130431   

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130431(US8822505, 33)
Affinity DataIC50: 89.5nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
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TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130431(US8822505, 33)
Affinity DataIC50: 3.54nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent