BDBM130414 US8822505, 14::US8822505, 16

SMILES CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl)c1ncc(Br)cc1F

InChI Key InChIKey=MZKPXTUNCMRSJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 130414   

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130414(US8822505, 16 | US8822505, 14)
Affinity DataIC50: 12.5nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130414(US8822505, 16 | US8822505, 14)
Affinity DataIC50: 39.8nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130414(US8822505, 16 | US8822505, 14)
Affinity DataIC50: 0.613nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130414(US8822505, 16 | US8822505, 14)
Affinity DataIC50: 0.525nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent