BDBM130413 US8822505, 13

SMILES Fc1cc(Br)cnc1C1(CNC1)C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccccc1Cl

InChI Key InChIKey=NSNODLMCUTYBRZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 130413   

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 4.60nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 1.09nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 1nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed