BDBM130409 US8822505, 9

SMILES FC(F)CN1CC(C1)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccc(OCC(F)(F)F)cc1Cl)c1ccc(Br)cn1

InChI Key InChIKey=ORVBPDVWWASNIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 130409   

TargetProcathepsin L(Human)
Genentech

US Patent
LigandPNGBDBM130409(US8822505, 9)
Affinity DataIC50: 91.7nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Genentech

US Patent
LigandPNGBDBM130409(US8822505, 9)
Affinity DataIC50: 0.779nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent