BDBM12985 5-Amido-pyrrolopyrazole 9d::CHEMBL402548::N-{5-[(2R)-2-methoxy-2-phenylacetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methylpiperazin-1-yl)benzamide

SMILES CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1

InChI Key InChIKey=XKFTZKGMDDZMJI-UHFFFAOYSA-N

Data  3 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 12985   

TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 79nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 79nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 61nMAssay Description:Inhibition of aurora C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 79nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 61nMAssay Description:Inhibition of Aurora C kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Aurora A (unknown origin) by biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 79nMAssay Description:Inhibition of Aurora B (unknown origin) by biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataKi:  13nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataKi:  61nMAssay Description:Inhibition of Aurora C kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataKi:  79nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed