BDBM12975 (2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-3-(1H-indol-3-yl)propanamido]-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamide::alpha-ketothiazole analogue 35

SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1

InChI Key InChIKey=RXTVQIZDVTYZLH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12975   

TargetCoagulation factor XI(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12975((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...)
Affinity DataIC50: 29nMAssay Description:Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12975((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...)
Affinity DataIC50: 2.10E+3nMAssay Description:Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12975((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...)
Affinity DataIC50: 710nMAssay Description:Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2007
Entry Details Article
PubMed