BDBM1287 3-Aminopyridin-2(1H)-one analogue 7::3-[(1,3-benzothiazol-2-ylmethyl)amino]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL431274::Pyridinone deriv. 4

SMILES CCc1cc(NCc2nc3ccccc3s2)c(=O)[nH]c1C

InChI Key InChIKey=YYFIAMJITQWHCZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 1287   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Organon Research and Development Group

Curated by ChEMBL
LigandPNGBDBM1287(3-[(1,3-benzothiazol-2-ylmethyl)amino]-5-ethyl-6-m...)
Affinity DataIC50: 347nMAssay Description:Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1287(3-[(1,3-benzothiazol-2-ylmethyl)amino]-5-ethyl-6-m...)
Affinity DataIC50: 350nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1287(3-[(1,3-benzothiazol-2-ylmethyl)amino]-5-ethyl-6-m...)
Affinity DataIC50: 350nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed