BDBM125914 US8765727, 17

SMILES Nc1ccc2CNc3nc(Nc4cncc(CCc1c2)c4)ncc3Cl

InChI Key InChIKey=FKLWUWJYBORMDH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 125914   

TargetALK tyrosine kinase receptor(Human)
Incyte

US Patent
LigandPNGBDBM125914(US8765727, 17)
Affinity DataIC50: 1.00E+3nMpH: 7.8Assay Description:HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandPNGBDBM125914(US8765727, 17)
Affinity DataIC50: 102nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte

US Patent
LigandPNGBDBM125914(US8765727, 17)
Affinity DataIC50: 447nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Incyte

US Patent
LigandPNGBDBM125914(US8765727, 17)
Affinity DataIC50: 114nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Incyte

US Patent
LigandPNGBDBM125914(US8765727, 17)
Affinity DataIC50: 386nMAssay Description:TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent