BDBM125912 US8765727, 15

SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(c(CNc1n2)c4)-c1ccccc1)c3

InChI Key InChIKey=JHMLRNFFLKYFAU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 125912   

TargetALK tyrosine kinase receptor(Human)
Incyte

US Patent
LigandPNGBDBM125912(US8765727, 15)
Affinity DataIC50: 1.00E+3nMpH: 7.8Assay Description:HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...More data for this Ligand-Target Pair
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Date in BDB:
11/24/2014
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandPNGBDBM125912(US8765727, 15)
Affinity DataIC50: 81nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Incyte

US Patent
LigandPNGBDBM125912(US8765727, 15)
Affinity DataIC50: 41nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Incyte

US Patent
LigandPNGBDBM125912(US8765727, 15)
Affinity DataIC50: 31nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Incyte

US Patent
LigandPNGBDBM125912(US8765727, 15)
Affinity DataIC50: 400nMAssay Description:TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
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