BDBM125059 US8765733, 24

SMILES CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1ccc(CNS(C)(=O)=O)c(F)c1)C(F)(F)F

InChI Key InChIKey=NAXMRUCVDLYTPD-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 125059   

LigandPNGBDBM125059(US8765733, 24)
Affinity DataKi:  5nMAssay Description:The FLIPR protocol consists of 2 substance additions. First the compounds to be tested (10 μM) are pipetted onto the cells and the Ca2+ influx i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent

LigandPNGBDBM125059(US8765733, 24)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]-resiniferatoxin from human TRPV1 expressed in CHO cells incubated for 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2017
Entry Details Article
PubMed
LigandPNGBDBM125059(US8765733, 24)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in CHO cell membranes after 45 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
LigandPNGBDBM125059(US8765733, 24)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPOU from human TRPV1 expressed in CHO cell membranes after 45 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
LigandPNGBDBM125059(US8765733, 24)
Affinity DataKi:  13nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ uptake incubated for 5 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2017
Entry Details Article
PubMed