BDBM124897 US8759338, 1

SMILES NC1CCCC(=C1)c1ccncc1Nc1cccc2cnc(nc12)-c1c(F)cccc1F

InChI Key InChIKey=VWDOGNVHWKGFOS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 124897   

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis

US Patent
LigandPNGBDBM124897(US8759338, 1)
Affinity DataIC50: 152nMpH: 7.5Assay Description:The activity of PIM1 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from kinase-catalyzed p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM124897(US8759338, 1)
Affinity DataIC50: 392nMpH: 7.5Assay Description:The activity of PIM2 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from kinase-catalyzed p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandPNGBDBM124897(US8759338, 1)
Affinity DataIC50: 78nMpH: 7.5Assay Description:The activity of PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from kinase-catalyzed p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
Go to US Patent