BDBM124296 US8759537, 33

SMILES Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)cc3F)c(OCC(F)F)cc12

InChI Key InChIKey=BPHPOXOCKDIPBH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 124296   

TargetProstaglandin E synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124296(US8759537, 33)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
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TargetProstaglandin E synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124296(US8759537, 33)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human mPGES-1 expressed in Escherichia coli Rosetta microsomes assessed as reduction in conversion of PGH2 to PGE2 incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124296(US8759537, 33)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human mPGES1 using PGH2 as substrate pretreated for 25 mins followed by substrate addition measured after 60 secs by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed