BDBM123748 1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (6)::1-tert-butyl-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (6)

SMILES Cc1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key InChIKey=ZHDZHTWFFPWUPB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 123748   

TargetPhospholipase D1(Human)
University of Massachusetts Boston

LigandPNGBDBM123748(1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 350nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
University of Massachusetts Boston

LigandPNGBDBM123748(1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 1.30E+3nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D(Streptomyces sp. PMF)
University of Massachusetts Boston

LigandPNGBDBM123748(1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 790nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D(Streptomyces chromofuscus)
Roxbury Community College

LigandPNGBDBM123748(1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 350nMpH: 8.0Assay Description:A NaOH stock solution (50 mM) was standardized with KHP then diluted in Millipore water (10-fold serial dilutions) then used to hold the pH constant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed