BDBM123331 US8742106, 1.18

SMILES CC(NC(=O)COc1cc(c2c(nn(C)c2n1)-c1ccccc1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=OFEXDHUBLMOHCY-UHFFFAOYSA-N

Data  4 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 123331   

TargetOrexin/Hypocretin receptor type 1(Human)
Novartis

US Patent
LigandPNGBDBM123331(US8742106, 1.18)
Affinity DataKd:  36nMpH: 7.5 T: 2°CAssay Description:For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Novartis

US Patent
LigandPNGBDBM123331(US8742106, 1.18)
Affinity DataKd:  63nMpH: 7.5 T: 2°CAssay Description:For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Novartis

US Patent
LigandPNGBDBM123331(US8742106, 1.18)
Affinity DataKi:  78nMAssay Description:Antagonist activity against human orexin 2 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Novartis

US Patent
LigandPNGBDBM123331(US8742106, 1.18)
Affinity DataKi:  88nMAssay Description:Displacement of [125l]orexin A from human orexin 1 receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Novartis

US Patent
LigandPNGBDBM123331(US8742106, 1.18)
Affinity DataKi:  120nMAssay Description:Antagonist activity against human orexin 1 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Novartis

US Patent
LigandPNGBDBM123331(US8742106, 1.18)
Affinity DataKi:  168nMAssay Description:Displacement of [125l]orexin A from human orexin 2 receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed