BDBM123216 US8742110, 3-1

SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)cc(OCC)c1-c1ccc(F)cc1

InChI Key InChIKey=KKHVNUWBIYHFEO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 123216   

TargetSomatostatin receptor type 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM123216(US8742110, 3-1)
Affinity DataIC50: 0.768nMpH: 7.8Assay Description:SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2014
Entry Details
Go to US Patent

TargetSomatostatin receptor type 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM123216(US8742110, 3-1)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM123216(US8742110, 3-1)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSomatostatin receptor type 5(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM123216(US8742110, 3-1)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at mouse SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed