BDBM12320 5-[(1E)-(methoxyimino)methyl]-6-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-4-amine::oxime analog 9

SMILES CO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1

InChI Key InChIKey=MIUKVPKHKILETL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12320   

TargetVascular endothelial growth factor receptor 2(Rat)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM12320(5-[(1E)-(methoxyimino)methyl]-6-[(2-methyl-1H-indo...)
Affinity DataIC50: 146nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM12320(5-[(1E)-(methoxyimino)methyl]-6-[(2-methyl-1H-indo...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed