BDBM12301 1,1-Dimethylethyl-[1(S)-[[(1R,5S)-2(S)-[[[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]amino]carbonyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]carbonyl]-2-hydroxy-2-methylpropyl]carbamates::SCH 503034 Analogue 60::tert-butyl N-[(2S)-1-[(1R,2S,5S)-2-[(1-carbamoyl-3-cyclobutyl-1-oxopropan-2-yl)carbamoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-3-hydroxy-3-methyl-1-oxobutan-2-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C)C(C)(C)O

InChI Key InChIKey=PJSAWWDUUOIIRD-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12301   

TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM12301(tert-butyl N-[(2S)-1-[(1R,2S,5S)-2-[(1-carbamoyl-3...)
Affinity DataKi:  220nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2006
Entry Details Article
PubMed