BDBM122512 US8729061, 42

SMILES CCC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccc(Cl)cc1Cl)C(=O)C(=O)NC1CC1

InChI Key InChIKey=HBSWEZXYFZOCOH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 122512   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM122512(US8729061, 42)
Affinity DataIC50: 0.634nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
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TargetProcathepsin L(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM122512(US8729061, 42)
Affinity DataIC50: 11.7nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
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TargetCathepsin K(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM122512(US8729061, 42)
Affinity DataIC50: 28.7nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM122512(US8729061, 42)
Affinity DataIC50: 115nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent