BDBM12195 2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-1-(2,3-dihydro-1H-isoindol-2-yl)butane-1,4-dione::isoquinoline derivative 18

SMILES NC(CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1

InChI Key InChIKey=ZKIQFLSGMMYCGS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12195   

TargetDipeptidyl peptidase 8(Human)
National Health Research Institutes

LigandPNGBDBM12195(2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-...)
Affinity DataIC50: 14nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
National Health Research Institutes

LigandPNGBDBM12195(2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
National Health Research Institutes

LigandPNGBDBM12195(2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-...)
Affinity DataIC50: 3.84E+4nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM12195(2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2020
Entry Details Article
PubMed