BDBM12109 1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 17::4-(4-Methyl-piperazin-1-yl)-N-(5-phenylacetyl-1,4,5,6-tetrahydro-pyrrolo[3,4-c]pyrazol-3-yl)-benzamide::4-(4-methylpiperazin-1-yl)-N-[5-(2-phenylacetyl)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl]benzamide::5-Amido-pyrrolopyrazole 2::CHEMBL190252

SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1ccccc1

InChI Key InChIKey=LZTPJGBYVKLMTF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12109   

TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12109(CHEMBL190252 | 4-(4-methylpiperazin-1-yl)-N-[5-(2-...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12109(CHEMBL190252 | 4-(4-methylpiperazin-1-yl)-N-[5-(2-...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12109(CHEMBL190252 | 4-(4-methylpiperazin-1-yl)-N-[5-(2-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed