BDBM120114 US8697715, 173::US9259470, 173

SMILES CCn1cc(Nc2nccc(n2)-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)c(C)n1

InChI Key InChIKey=ULOBOPPHTKWOKZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 120114   

TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120114(US8697715, 173 | US9259470, 173)
Affinity DataIC50: 5.70nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120114(US8697715, 173 | US9259470, 173)
Affinity DataIC50: 5.70nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120114(US8697715, 173 | US9259470, 173)
Affinity DataIC50: 18nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120114(US8697715, 173 | US9259470, 173)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120114(US8697715, 173 | US9259470, 173)
Affinity DataIC50: 18nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120114(US8697715, 173 | US9259470, 173)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed