BDBM11985 4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid::Salicylic acid derivative, compound 1::chemical diversity library compound 10

SMILES Cc1ccc(C)n1-c1ccc(C(O)=O)c(O)c1

InChI Key InChIKey=WAYCNXGAKFXIKA-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11985   

TargetEphrin type-A receptor 4 [1-949,A922V](Human)
Sanford-Burnham Medical Research Institute

LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataIC50: 1.30E+3nMpH: 7.5Assay Description:Protein A-coasted wells (from Pierce Biotechnology) were used to immobilize Eph receptor Fc fusion proteins (from R&D systems)incubated at 1 ug/ml in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetReplicative DNA helicase(Staphylococcus aureus)
Microbiotix

Curated by ChEMBL
LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Staphylococcus aureus Smith DNA helicase DnaC assessed as strand unwinding after 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataKi:  1.50E+3nM ΔG°:  -7.99kcal/mole IC50: 3.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2006
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataKi:  1.28E+4nMAssay Description:Inhibition of recombinant vaccina H1-related phosphatase expressed in Escherichia coli by Michaelis-Menten kinetic studiesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed