BDBM119812 US20240034730, Compound ASLAN003::US8691852, 20

SMILES COc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)c(F)c1

InChI Key InChIKey=OMPATGZMNFWVOH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 119812   

LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 15nMpH: 8.0Assay Description:DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2014
Entry Details
Go to US Patent

LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 15nMAssay Description:Inhibition of Homo sapiens (human) dehydroorotate dihydrogenase using 2,6-dichlorophenol-indophenol as substrate after 10 min by spectrophotometric a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 44nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 35nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 44nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM119812(US8691852, 20 | US20240034730, Compound ASLAN003)
Affinity DataIC50: 44nMAssay Description:Inhibition of human DHODH incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed