BDBM119741 US8680132, MI- 710601::US9079913, MI-710601

SMILES CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NC1CC[C@H](O)CC1

InChI Key InChIKey=PSABHJAMVJLCQH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 119741   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119741(US8680132, MI- 710601 | US9079913, MI-710601)
Affinity DataIC50: 290nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was optionally determined using a fluorescence polarization-based (FP-based) binding assay using a recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119741(US8680132, MI- 710601 | US9079913, MI-710601)
Affinity DataIC50: 256nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was optionally determined using a fluorescence polarization-based (FP-based) binding assay using a recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119741(US8680132, MI- 710601 | US9079913, MI-710601)
Affinity DataIC50: 20.1nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119741(US8680132, MI- 710601 | US9079913, MI-710601)
Affinity DataIC50: 100nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent