BDBM119732 US8680132, C03401::US9079913, C03401

SMILES CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@@](C)(O)C1

InChI Key InChIKey=DFNKYRCFAIHHQB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 119732   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119732(US8680132, C03401 | US9079913, C03401)
Affinity DataIC50: 108nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was optionally determined using a fluorescence polarization-based (FP-based) binding assay using a recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119732(US8680132, C03401 | US9079913, C03401)
Affinity DataIC50: 85.6nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was optionally determined using a fluorescence polarization-based (FP-based) binding assay using a recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119732(US8680132, C03401 | US9079913, C03401)
Affinity DataIC50: 18nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandPNGBDBM119732(US8680132, C03401 | US9079913, C03401)
Affinity DataIC50: 100nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent