BDBM119703 US8685992, 27

SMILES COc1ccc(cc1)-c1cc(-c2ccoc2)c([nH]1)C(=O)NCc1ccc(cc1)C(=O)NO

InChI Key InChIKey=VWPYPJQYNJIVCP-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 119703   

TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 70nMAssay Description:Inhibition of C-terminal GST-tagged full length human HDAC1 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 160nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus expression system after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 160nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC11 expressed in baculovirus expression systemRHKAcKAc after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 290nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC10 (1 to 631 residues) expressed in baculovirus expression system in Sf9 cells RHKAcKAc after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 150nMAssay Description:Inhibition of full length human HDAC8 expressed in an E. coli expression system using AMC-labeled RHKAcKAc as substrate after 2 hrs by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 290nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus expression system using AMC-labeled RHKKAc as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 220nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC5 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC4 (627 to 1085 residues) expressed in baculovirus expression system using AMC-labeled RHKKAc as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 80nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC3 expressed in baculovirus expression system using AMC-labeled RHKKAc as substrate after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 71nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 341nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 294nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 163nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 148nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 290nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 1.60nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 222nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 1.08E+3nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 75nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50: 157nMT: 2°CAssay Description:The reactions were carried out in a 96-well microplate for fluorometry in a 50 μl reaction volume. After the deacetylation reaction, Fluor-de-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
Go to US Patent