BDBM119448 US8686018, 107

SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O

InChI Key InChIKey=MKLKAQMPKHNQPR-UHFFFAOYSA-N

Data  1 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 119448   

TargetProstaglandin E2 receptor EP2 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP2 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at EP4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at EP3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 928nMAssay Description:Antagonist activity at EP2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at EP1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP formation preincubated for 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as reduction in PGE2-mediated cAMP accumulation preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP3 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP1 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at mouse EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 181nMAssay Description:Antagonist activity at mouse EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP2 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP1 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP3 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arromax Pharmatech Co.

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataKi:  8nMpH: 7.4Assay Description:The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
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