BDBM119402 US8669361, 231::US9573943, Example 231

SMILES CN1CCC(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C

InChI Key InChIKey=UWKVKWLSOMBHTE-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 119402   

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119402(US8669361, 231 | US9573943, Example 231)
Affinity DataKi:  5.26nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119402(US8669361, 231 | US9573943, Example 231)
Affinity DataKi:  5.26nM ΔG°:  -11.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119402(US8669361, 231 | US9573943, Example 231)
Affinity DataKi:  7.65nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119402(US8669361, 231 | US9573943, Example 231)
Affinity DataKi:  7.65nM ΔG°:  -11.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119402(US8669361, 231 | US9573943, Example 231)
Affinity DataKi:  201nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119402(US8669361, 231 | US9573943, Example 231)
Affinity DataKi:  201nM ΔG°:  -9.13kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent