BDBM11911 (2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxyadamantan-1-yl)acetamide::seco-proline-based inhibitor 27

SMILES [H][C@@](N)(C(=O)N(CC)CC#N)[C@@]12CC3CC(CC(O)(C3)C1)C2

InChI Key

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11911   

TargetDipeptidyl peptidase 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11911((2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxya...)
Affinity DataKi:  3nM ΔG°:  -11.5kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed