BDBM118731 US11667644, Example 387::US8653263, 387::US9586962, Example 387::USRE48841, Example 387

SMILES Fc1cc2ncc(nc2cc1F)N1CC2CN(CC2C1)C(=O)c1cccc(F)c1-c1ncccn1

InChI Key InChIKey=JAPHEZZFBLTLBW-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 118731   

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  16nMAssay Description:The in vitro affinity of the compounds for the human orexin-1 and orexin-2 receptors was determined by competitive radioligand binding using [3H]SB S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  16nM ΔG°:  -10.6kcal/moleT: 2°CAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  16nMAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  16nMAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  437nMAssay Description:The in vitro affinity of the compounds for the human orexin-1 and orexin-2 receptors was determined by competitive radioligand binding using [3H]SB S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  437nM ΔG°:  -8.67kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  437nMAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM118731(US8653263, 387 | US9586962, Example 387 | USRE4884...)
Affinity DataKi:  437nMAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent