BDBM11867 CHEMBL234350::N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-1-(2-phenylethyl)piperidine-4-carboxamide Hydrochloride::N-hydroxy-4-{[(4-phenoxybenzene)sulfonyl]methyl}-1-(2-phenylethyl)piperidine-4-carboxamide hydrochloride::beta-sulfone 7d

SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCN(CCc2ccccc2)CC1

InChI Key InChIKey=PUHDBKGWNNZTBP-UHFFFAOYSA-N

Data  6 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 11867   

TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: 700nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: 43nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  1.10nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  3nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  9nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  42.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  700nM ΔG°:  -8.39kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed