BDBM118234 US8653092, 1

SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1

InChI Key InChIKey=VHBAXDNZLJTAHW-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 118234   

LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 2.04E+3nMAssay Description:Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 15nMAssay Description:Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 6.79E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 143nMAssay Description:Inhibition of recombinant human myristoylated PI3Kdelta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 15nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidylinositol as substrate after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol as substrate after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 6.79E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidyl inositol as substrate measured after 30 mins by Alexa Fluor647-labelled ADP tracer based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 98nMAssay Description:Inhibition of PI3Kdelta in Balb/c mouse splenocytes assessed as reduction in anti-IgM stimulated CD86 expression pretreated for 1 hr followed by anti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 76nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins by Alexa Fluor647-labelled ADP tracer based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of [33P]ATP by Scintillation pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM118234(US8653092, 1)
Affinity DataIC50: 15nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of [33P]ATP by Scintillation pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed