BDBM117012 US8637532, 739

SMILES CNC[C@H](c1cccc(c1)F)Nc2c3cccc(c3ncn2)C(=O)N

InChI Key InChIKey=RBMOLIOJAWRTIV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 117012   

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed