BDBM116525 US8637532, 211

SMILES CNCC(Nc1ncnc2c(cccc12)C(N)=O)c1cccc(F)c1

InChI Key InChIKey=RBMOLIOJAWRTIV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 116525   

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50: 0.950nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Merck Patent

US Patent
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50: 230nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed