BDBM116244 US10035794, Example 20::US10683287, Example 20::US8637508, 20

SMILES C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2Cl)C#N)n1

InChI Key InChIKey=DPIDWDAWIQYLLV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 116244   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 41nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 41nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 5nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 10nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 41nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent