BDBM116240 US10035794, Example 16::US10683287, Example 16::US8637508, 16

SMILES Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N

InChI Key InChIKey=VAFUDQUXHDFJQT-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 116240   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 82nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 55nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 82nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 55nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 77nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human BACE1 extracellular domain expressed in baculovirus using fluorescence-quenched peptide substrate derived from APP se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 82nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 55nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCathepsin D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human Cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCathepsin E(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human Cathepsin E using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 98nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed