BDBM11550 N-hydroxy-2-[(2-methyl-1,1-biphenyl-4-yl)methyl]isothiazolidine-3-carboxamide 1,1-dioxide::N-hydroxy-2-{[4-(2-methylphenyl)phenyl]methyl}-1,1-dioxo-1,2-thiazolidine-3-carboxamide::Sultam Hydroxamate 15c

SMILES Cc1ccccc1-c1ccc(CN2C(CCS2(=O)=O)C(=O)NO)cc1

InChI Key InChIKey=QDICWLMZEKDVEQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11550   

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM11550(N-hydroxy-2-[(2-methyl-1,1-biphenyl-4-yl)methyl]is...)
Affinity DataKi: >2.13E+3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11550(N-hydroxy-2-[(2-methyl-1,1-biphenyl-4-yl)methyl]is...)
Affinity DataKi: >3.33E+3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11550(N-hydroxy-2-[(2-methyl-1,1-biphenyl-4-yl)methyl]is...)
Affinity DataKi: >4.95E+3nM ΔG°: >-7.23kcal/molepH: 7.5 T: 2°CAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM11550(N-hydroxy-2-[(2-methyl-1,1-biphenyl-4-yl)methyl]is...)
Affinity DataKi: >5.03E+3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed