BDBM11549 2-[(3,5-dichloro-1,1-biphenyl-4-yl)methyl]-N-hydroxyisothiazolidine-3-carboxamide 1,1-dioxide::2-{[4-(3,5-dichlorophenyl)phenyl]methyl}-N-hydroxy-1,1-dioxo-1,2-thiazolidine-3-carboxamide::Sultam Hydroxamate 15b

SMILES ONC(=O)C1CCS(=O)(=O)N1Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=LLVLFZAKVKFNSB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11549   

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM11549(2-{[4-(3,5-dichlorophenyl)phenyl]methyl}-N-hydroxy...)
Affinity DataKi: >2.13E+3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11549(2-{[4-(3,5-dichlorophenyl)phenyl]methyl}-N-hydroxy...)
Affinity DataKi: >3.33E+3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11549(2-{[4-(3,5-dichlorophenyl)phenyl]methyl}-N-hydroxy...)
Affinity DataKi: >4.95E+3nM ΔG°: >-7.23kcal/molepH: 7.5 T: 2°CAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM11549(2-{[4-(3,5-dichlorophenyl)phenyl]methyl}-N-hydroxy...)
Affinity DataKi: >5.03E+3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed