BDBM115297 US8637500, 106

SMILES C1CN(CCO1)c1nccnc1Oc1ccc(Nc2ccccn2)cc1

InChI Key InChIKey=VGCLMLVSRISONU-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 115297   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Amgen

Curated by ChEMBL

LigandBDBM115297(US8637500, 106)Copy SMILESCopy InChI

Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/1/2020
Entry Details Article
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Amgen

US Patent

LigandBDBM115297(US8637500, 106)Copy SMILESCopy InChI

Affinity DataIC50: 38nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/22/2014
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL