BDBM115187 N‐(3‐chloro‐4‐methoxyphenyl)‐8‐methoxy‐2‐ (thiomorpholine‐4‐carbonyl)quinolin‐4‐amine::UT-A1 inhibitor A6

SMILES COc1ccc(Nc2cc(nc3c(OC)cccc23)C(=O)N2CCSCC2)cc1Cl

InChI Key InChIKey=SPAHXDCPFHVVMV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 115187   

TargetUrea transporter 2(Rat)
University of California San Francisco

LigandPNGBDBM115187(N‐(3‐chloro‐4‐methoxypheny...)
Affinity DataIC50: 1.90E+4nMAssay Description:The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details Article
PubMed
TargetUrea transporter 1(Rat)
University of California San Francisco

LigandPNGBDBM115187(N‐(3‐chloro‐4‐methoxypheny...)
Affinity DataIC50: 2.70E+4nMAssay Description:Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details Article
PubMed