BDBM1144 (4R,5R,6R)-1-[(3-aminophenyl)methyl]-4-benzyl-5-hydroxy-3-(1H-indazol-5-ylmethyl)-6-(2-phenylethyl)-1,3-diazinan-2-one::(4R,5R,6R)-Tetrahydro-1-[1H-indazol-5-ylmethyl]-3-(3-aminophenyl-methyl)-4-(2-phenylethyl)-5-hydroxy)-6-(phenylmethyl)-2(1H)-pyrimidinone::Tetrahydropyrimidinone deriv. 92

SMILES Nc1cccc(CN2[C@H](CCc3ccccc3)[C@@H](O)[C@@H](Cc3ccccc3)N(Cc3ccc4[nH]ncc4c3)C2=O)c1

InChI Key InChIKey=MMUOMMUDZAEDSY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1144   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Missouri-St. Louis

Curated by ChEMBL
LigandPNGBDBM1144((4R,5R,6R)-Tetrahydro-1-[1H-indazol-5-ylmethyl]-3-...)
Affinity DataKi:  0.0794nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1144((4R,5R,6R)-Tetrahydro-1-[1H-indazol-5-ylmethyl]-3-...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Missouri-St. Louis

Curated by ChEMBL
LigandPNGBDBM1144((4R,5R,6R)-Tetrahydro-1-[1H-indazol-5-ylmethyl]-3-...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Missouri-St. Louis

Curated by ChEMBL
LigandPNGBDBM1144((4R,5R,6R)-Tetrahydro-1-[1H-indazol-5-ylmethyl]-3-...)
Affinity DataKi:  0.0802nMAssay Description:Inhibitory activity of compound against HIV-1 aspartyl protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed