BDBM11429 4-({5-[(4-aminocyclohexyl)amino]-3-cyclopentylpyrazolo[1,5-a]pyrimidin-7-yl}amino)-N,N-dimethylbenzene-1-sulfonamide::pyrazolo[1,5-a]pyrimidine 9b

SMILES CN(C)S(=O)(=O)c1ccc(Nc2cc(N[C@H]3CC[C@H](N)CC3)nc3c(cnn23)C2CCCC2)cc1

InChI Key InChIKey=OFKPBSZSSNDQJL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 11429   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11429(4-({5-[(4-aminocyclohexyl)amino]-3-cyclopentylpyra...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Martin-Luther-University Halle-Wittenberg

LigandPNGBDBM11429(4-({5-[(4-aminocyclohexyl)amino]-3-cyclopentylpyra...)
Affinity DataIC50: 2.20E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM11429(4-({5-[(4-aminocyclohexyl)amino]-3-cyclopentylpyra...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed