BDBM11337 2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxypropanamide::CHEMBL316169::Hydroxamate 18

SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(C)C(=O)NO

InChI Key InChIKey=JRCGNOYYZQLNTH-UHFFFAOYSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 11337   

TargetMacrophage metalloelastase(Mouse)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  15nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  15nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  19nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCollagenase ColG(Hathewaya histolytica)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  20nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  35nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  58nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  86nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  120nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  136nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi

LigandPNGBDBM11337(CHEMBL316169 | 2-[benzyl(4-methoxybenzene)sulfonam...)
Affinity DataKi:  195nM ΔG°:  -9.15kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed