BDBM112572 US8618103, I-68

SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncncc1-c1cnc2[nH]ccc2n1

InChI Key InChIKey=GLYUNTYKVSBASO-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 112572   

TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112572(US8618103, I-68)
Affinity DataIC50: 0.181nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM112572(US8618103, I-68)
Affinity DataIC50: 199nMAssay Description:Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112572(US8618103, I-68)
Affinity DataIC50: 181nMAssay Description:Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM112572(US8618103, I-68)
Affinity DataIC50: 37nMAssay Description:Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM112572(US8618103, I-68)
Affinity DataKi:  0.0188nM IC50: 0.0366nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
Go to US Patent