BDBM111998 US8618107, 312

SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCN(CC2)C2COC2)c1=O)-c1cccc(N2CCc3c4CC(C)(C)Cc4sc3C2=O)c1CO

InChI Key InChIKey=OOVUFAWLHUGLLC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 111998   

TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111998(US8618107, 312)
Affinity DataIC50: 43nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111998(US8618107, 312)
Affinity DataIC50: 4nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Genentech

Curated by ChEMBL
LigandPNGBDBM111998(US8618107, 312)
Affinity DataIC50: 6nMAssay Description:Inhibition of BTK in goat F(ab')2anti-mouse IgM-stimulated Balb/c mouse splenocyte B cells assessed as suppression of BCR-mediated CD86 induction pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111998(US8618107, 312)
Affinity DataIC50: 89nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMed