BDBM111831 US8623906, JHE-02-068A::US9174969, JHE-02-068A

SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)Nc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=URSVIOSQNCZMFN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 111831   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM111831(US8623906, JHE-02-068A | US9174969, JHE-02-068A)
Affinity DataIC50: 5.70E+3nMAssay Description:In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2014
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM111831(US8623906, JHE-02-068A | US9174969, JHE-02-068A)
Affinity DataIC50: 5.70E+3nMAssay Description:IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
Go to US Patent