BDBM111814 2,5-Bis[4-(methylaminoethanol)benzylidene] cyclopentanone (13)

SMILES CNC(CO)c1ccc(\C=C2/CC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1

InChI Key InChIKey=IWHUAXPYFPCCJG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 111814   

TargetPhospholipase A2(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111814(2,5-Bis[4-(methylaminoethanol)benzylidene] cyclope...)
Affinity DataIC50: 1.91E+4nMpH: 8.0 T: 2°CAssay Description:Substrate 1,2-bis(heptanoylthio)-glycerophosphocholine and human recombinant PLA2-V were resuspended in assay buffer, and DTNB was dissolved in an aq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111814(2,5-Bis[4-(methylaminoethanol)benzylidene] cyclope...)
Affinity DataIC50: 3.59E+4nMpH: 8.0 T: 2°CAssay Description:Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetLipoxygenase(Soybean)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111814(2,5-Bis[4-(methylaminoethanol)benzylidene] cyclope...)
Affinity DataIC50: 8.95E+4nMpH: 7.0 T: 2°CAssay Description:The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111814(2,5-Bis[4-(methylaminoethanol)benzylidene] cyclope...)
Affinity DataIC50: 3.78E+3nMpH: 7.0 T: 2°CAssay Description:The assay buffer contained 100 mM KHPO4 (pH 7.0), 2 mM EDTA and 2.5 mM reduced GSH. 100 µL of reaction buffer containing human recombinant mPGES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed